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Upon secretion, procollagen undergoes three steps of transformation in the extracellular space, i.e., (1) enzymatic removal of the free endings by procollagen peptidase to give rise to tropocollagen, (2) cross-linking of tropocollagen molecules to form collagen fibrils by lysyl oxidase, and (3) side-by-side cross-linking of collagen fibrils to form collagen fibers [54]

Sleep fragmentation induces AQP4 mislocalization from astrocytic endfeet, reducing CSF clearance efficiency